Self-Nanoemulsifying Drug Delivery System (SNEDDS) of piroxicam

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that commonly used for arthritis, gout, and other musculoskeletal disorders. poorly soluble in water according to the biopharmaceutical classification system (BCS) classified as Class II with good permeability but poor dissolution. The self-nanoemulsifying delivery (SNEDDS) has been extensively employed improve dissolution absorption of water-insoluble drugs within gastrointestinal tract, leading enhanced oral bioavailability increased therapeutic effect loaded drugs. Therefore, present study aims evaluate activity piroxicam-loaded SNEDDS compared conventional piroxicam suspension was observed male Wistar strain rats. tailored from mixture oleic acid, tween 80, propylene glycol. Twenty rats (aged 2-3 months, weighed 150-250g) were selected divided equally into 4 different groups receiving 1% PVP, carrier, (1.8 mg/Kg BW), BW). Acute inflammation induced by carrageenan-induced paw edema model where carrageenan injected sub plantar hind induce edema. Several parameters including volume, AUC 0-6 , percent effect, measured experienced each group. At end this study, group significantly demonstrated better protection (ρ<0.05), suggesting may enhance piroxicam.